Tγ and theophylline-sensitive T lymphocytes in allergic contact dermatitis

✍ Scribed by G. Angelini; G. A. Vena; R. D'Ovidio; C. L. Meneghini

• Book ID: 104762064
• Publisher: Springer-Verlag
• Year: 1982
• Tongue: English
• Weight: 366 KB
• Volume: 273-273
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00409252

✦ Synopsis

Two lymphocyte subpopulations, T cells bearing a receptor for the Fc fragment of IgG (T7) and theophylline-sensitive T cells, were investigated in 49 patients with allergic contact dermatitis (ACD) in the acute phase and compared with a control group. Patients with ACD had markedly reduced relative T7 and theophylline-sensitive T lymphocyte levels, compared with normals (P< 0.0005). The patients also showed reduced absolute T7 and theophylline-sensitive T cells with respect to the controls (P < 0.01).

To determine whether decreased levels of T7 and theophylline-sensitive T cells were related to the activity of ACD, the same T-cell subsets were determined in 10 of 49 patients after the clearing of the contact dermatitis. Both T-cell subpopulations were found within the normal range.