Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling

✍ Scribed by E. H. Fischer, N. F. Zander, J. Lorenzen, C. Dadabay, D. E. Cool (auth.), Ludwig M. G. Heilmeyer Jr. (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1993
• Tongue: English
• Leaves: 375
• Series: NATO ASI Series 76
• Edition: 1
• Category: Library

✦ Synopsis

Nearly every cellular activity, such as cell growth, proliferation, protein synthesis, and nuclear division, is regulated by protein phosphorylation/dephosphorylation on tyrosine residues as initiation events.Synchronization occurs through interaction of protein tyrosine kinases and phosphatases. This book unveils signal pathways that connect extracellular signals with changes of phosphorylation state of target proteins allowing coordinated and integrated modulation of mitogenic signalling. Specifically, cascades involving protein serine/threonine kinases and connections to phosphoinositides derived second messengers are discussed.

✦ Table of Contents

Front Matter....Pages I-XI
Front Matter....Pages 1-1
Protein Tyrosine Phosphorylation-Dephosphorylation and Cell Signaling....Pages 3-9
Regulation and Functions of Src-Family Kinases: An Update....Pages 11-30
Mitogen-Activated Signalling Pathways....Pages 31-44
Studies of the very Early Responses of a Receptor Tyrosine Kinase to Growth Factor Binding and their Application to the Purification and Identification of Proteins that are Tyrosine Phosphorylated in the Growth Factor Response....Pages 45-62
The Role of P21 ras in Cell Signalling....Pages 63-68
The HGF/SF Receptor Kinase: Structure and Function....Pages 69-85
RET/ptc and TRK Oncogenes in Papillary Thyroid Carcinoma....Pages 87-98
Structure-Function Analysis of Hepatocyte Growth Factor and its Tyrosine-Kinase Receptor c-Met....Pages 99-102
Oncogenic Activation of the Met/HGF Receptor Tyrosine Kinase is Promoted by Leucine Zipper Mediated Dimerization....Pages 103-106
Specificity of the Truncated Form of Human T-cell Protein Tyrosine Phosphatase toward Phosphorylated Synthetic Peptides....Pages 107-110
Regulation of Tyrosine Protein Phosphatases by Binding to Phospholipids and Covalent Modification....Pages 111-114
Localization-Dependent Regulation of Lymphocyte Tyrosine Phosphatases....Pages 115-118
Protein Tyrosine Phosphatases in the Nematode Ascaris Suum ....Pages 119-122
Non-radioactive determination of phosphotyrosine phosphatase (PTPase) activity....Pages 123-126
New Protein Tyrosine Phosphatases from Vascular Smooth Muscle Cells: Transcript Levels in Tissues and in Cultured Cells....Pages 127-130
Recombinant CSK Expressed in E.Coli is Phosphorylated on Tyrosine Residue(s) and Undergoes in Vitro Phosphorylation....Pages 131-134
Polylysine Activates a Splenic Tyrosine Protein Kinase Encoded by the fgr Protooncogene....Pages 135-138
Protein Phosphorylation in the Signal Transduction of the Neuropeptide Bombesin in Swiss 3T3 Cells....Pages 139-142
Growth Hormone (GH) Increases Lipoprotein Lipase mRNA in Cells Transfected with the Rat GH Receptor cDNA....Pages 143-146
Front Matter....Pages 147-147
Role of Phosphatidylinositol 3-Kinase in Growth Factor and Oncogene Signaling....Pages 149-165
Front Matter....Pages 147-147
Isolation and Characterization of Phosphatidylinositol 4-Kinase Isoenzymes from Bovine Brain....Pages 167-170
Determination of Phosphoinositides and Inositol Phosphates. Principles and Rules....Pages 171-192
Phosphoinositides in Rabbit Skeletal Muscle Membranes....Pages 193-196
Renaturation of Phosphatidylinositol 4- and Phosphatidylinositol 4-Phosphate 5′-Kinases Following Polyacrylamide Gelelectrophoresis in Presence of SDS. Studies on their Substrate Binding Requirements Using Synthetic Substrate Analogues....Pages 197-200
Front Matter....Pages 201-201
The Catalytic Subunit of cAMP-Dependent Protein Kinase....Pages 203-213
Casein Kinase I and the Classification of Protein Kinases: What’s in a Name?....Pages 215-222
Downregulation of protein kinase C is associated with phenotypic changes and enhanced proliferation of vascular smooth muscle cells....Pages 223-226
Insulin-Stimulated Seryl/Threonyl Protein Kinases in Diabetic Rats and the Effects of Vanadium Treatment....Pages 227-230
Protein Phosphorylation in Prokaryotes — Evidence for PKC-Like Activities in Escherichia Coli ....Pages 231-234
Phosphorylation of Creatine Kinase in Myogenic Cells: Effects of Okadaic Acid and other Agents Affecting Cellular Protein Phosphorylation....Pages 235-240
Non-Radioactive Determination of Phosphoamino Acids by Capillary Electrophoresis....Pages 241-246
Characterization of Phosphoproteins by 31 P-NMR Spectroscopy....Pages 247-257
CK-2, a Multifunctional Protein Kinase and its Role during Proliferation....Pages 259-262
Front Matter....Pages 263-263
Molecular Complexity of Protein Phosphatase 2A Holoenzymes and Delineation of their Function....Pages 265-286
Dephosphorylation in Vitro Inhibits Ligand and DNA Binding Activities of Human Estrogen Receptor....Pages 287-290
Characterization of Novel Nuclear Inhibitors of Protein Phosphatase — 1....Pages 291-295
Front Matter....Pages 297-297
The Mitogen-Activated p70 s6k / p85 s6k ....Pages 299-309
Expression of the p70 s6k / p85 s6k Isoforms from a Single Gene and Activation Following Mitogenic Stimulation....Pages 311-316
Control of S6 phosphorylation in normal and v-src transformed cells....Pages 317-320
The Phosphorylated Ribosomal Protein in Tetrahymena is Homologous with Mammalian Ribosomal Protein S4....Pages 321-324
Front Matter....Pages 297-297
Nucleocytoplasmic Transport of Ribosomal Protein S6....Pages 325-328
Front Matter....Pages 329-329
Regulating the G 2 Checkpoint in the Cell Cycle....Pages 331-341
CD2-Dependence on the CD3-Zeta-Chain in T Cell Signalling — Shown by Inhibitory and Modifying Effects of Cholera Toxin....Pages 343-346
cdc25 protein phosphatase in mammalian fibroblasts: cell cycle expression and intracellular localization....Pages 347-350
Front Matter....Pages 351-351
The Role of Small Molecular Weight GTP-Binding Proteins in Stimulus Secretion Coupling of Pancreatic Acinar Cells....Pages 353-367
Characterization of Calcium Transport ATPase Isozymes in Different Blood Cells....Pages 369-372
Back Matter....Pages 373-380

✦ Subjects

Biochemistry, general; Cell Biology; Cancer Research