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Tyrosine phosphorylation of vinexin in v-Src-transformed cells attenuates the affinity for vinculin

✍ Scribed by Tsutomu Umemoto; Kana Tanaka; Kazumitsu Ueda; Noriyuki Kioka


Book ID
116298886
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
393 KB
Volume
387
Category
Article
ISSN
0006-291X

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## Abstract FAK (focal adhesion kinase) is a nonreceptor protein‐tyrosine kinase activated by tyrosine phosphorylation following integrin‐mediated cell adhesion. Oncogenic Src promotes enhanced and deregulated FAK tyrosine phosphorylation which has been proposed to contribute to altered cell growth