Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

CD16-mediated activation of phosphatidyl

CD16-mediated activation of phosphatidylinositol-3 kinase (Pl-3K) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2, Shc, pp36 and p85 Pl-3K subunit

✍ Cristina Cerboni; Angela Gismondi; Gabriella Palmieri; Mario Piccoli; Luigi Frat 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 214 KB 👁 2 views

Phosphatidylinositol 3-kinase (Pl-3K) plays a key role in several cellular processes, including mitogenesis, apoptosis, actin reorganization and vesicular trafficking. The molecular events involved in its activation have not been fully elucidated and several reports indicate that a key event for enz