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Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases

✍ Scribed by Bryan A. Ballif; Lionel Arnaud; Jonathan A. Cooper


Book ID
117386322
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
518 KB
Volume
117
Category
Article
ISSN
0169-328X

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## Abstract We examined the consequences of v‐Crk expression in mouse embryo fibroblasts deficient Src family kinases or p130CAS. We found that Src kinases are essential for p130CAS/v‐Crk signaling leading to FAK phosphorylation and cell migration in which Src is likely to mediate the focal adhesio