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Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2- d ]pyrimidines and Pyrimido[5,4- b ]- and -[4,5- b ]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase

✍ Scribed by Showalter, H. D. Hollis; Bridges, Alexander J.; Zhou, Hairong; Sercel, Anthony D.; McMichael, Amy; Fry, David W.


Book ID
118258756
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
315 KB
Volume
42
Category
Article
ISSN
0022-2623

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## Abstract Receptor tyrosine kinases such as VEGFR2 (vascular endothelial growth factor receptor 2, KDR) or EGFR (epidermal growth factor receptor) play crucial roles in a variety of diseases, such as cancer. Recently, some pyrrolopyrimidines were shown to be potent EGFR inhibitors. Therefore, new