✍ Scribed by Souery, D.; Lipp, O.; Rivelli, S.K.; Massat, I.; Serretti, A.; Cavallini, C.; Ackenheil, M.; Adolfsson, R.; Aschauer, H.; Blackwood, D.; Dam, H.; Dikeos, D.; Fuchshuber, S.; Heiden, M.; Jakovljevic, M.; Kaneva, R.; Kessing, L.; Lerer, B.; L�nnqvist, J.; Mellerup, T.; Milanova, V.; Muir, W.; Nylander, P.O.; Oruc, L.; Papadimitriou, G.N.; Pekkarinen, P.; Peltonen, L.; Pull, C.; Raeymaekers, P.; Shapira, B.; Smeraldi, E.; Staner, L.; Stefanis, C.; Verga, M.; Verheyen, G.; Macciardi, F.; Van Broeckhoven, C.; Mendlewicz, J.
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Tyrosine hydroxylase (TH) is a candidate gene extensively explored in several association studies of bipolar disorder (BD). However, because of conflicting results of independent studies and low statistical power of individual studies to detect small differences between cases and controls, reliable
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Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylas
Tyrosine hydroxylase (TH) is the ratelimiting enzyme in the synthesis of dopamine and norepinephrine. It may be involved in the pathophysiology of psychiatric disorders and positive associations have been reported for TH gene markers in mood disorders. While most replications failed to confirm the i