✦ LIBER ✦

Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer

✍ Scribed by Bernhard C. Pestalozzi; George A. Sotos; Peter L. Choyke; Jason S. Fisherman; Kenneth H. Cowan; Joyce A. O'Shaughnessy

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 381 KB
Volume: 71
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19930301)71:5<1797::aid-cncr2820710514>3.0.co;2-b

No coin nor oath required. For personal study only.

✦ Synopsis

Background.

Typhlitis is being recognized with in- creasing frequency as a serious complication of aggressive chemotherapy for hematologic and solid malignancies.

In this report the authors describe two cases of typhlitis in patients with metastatic breast cancer treated with taxol and doxorubicin.

Both cases occurred during the first cycle of treatment with taxol(l80 mg/mz) and doxorubicin (75 mg/m2), being given simultaneously as 72-hour continuous intravenous infusions.

Two cases of typhlitis have occurred after combined treatment with taxol and doxorubicin, while typhlitis has not been described after treatment with either drug alone.

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