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Type Iα phosphatidylinositol 4-phosphate 5-kinase is a putative target for increased intracellular phosphatidic acid

✍ Scribed by David R. Jones; Miguel A. Sanjuan; Isabel Mérida

Book ID
117101989
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
226 KB
Volume
476
Category
Article
ISSN
0014-5793

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## Abstract Type I phosphatidylinositol 4‐phosphate 5‐kinase (PI4P5K) catalyzes the phosphorylation of phosphatidylinositol 4 phosphate [PI(4)P] at carbon 5, producing phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2]. Phosphatidic acid (PA) activates PI4P5K in vitro and plays a central role in the