Type I diabetes mellitus in a patient with chromosome 22q11.2 deletion syndrome

✍ Scribed by Elder, Deborah A. ;Kaiser-Rogers, Kathleen ;Aylsworth, Arthur S. ;Calikoglu, Ali S.

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 76 KB
• Volume: 101
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/ajmg.1293

✦ Synopsis

We describe a patient with type I diabetes, clinical ®ndings consistent with velocardiofacial syndrome, and a chromosome 22q11.2 deletion. A nine-year-old boy presented with a history of polyuria, polydipsia, weight loss, hyperglycemia, ketosis, serum insulin antibodies, and a low C-peptide level. He had distinctive facial features, learning disabilities, short stature, and a history of glottic web and clubfoot. Although a normal karyotype was obtained, ¯uorescence in situ hybridization (FISH) revealed a submicroscopic deletion in the DiGeorge/velocardiofacial syndrome critical region at 22q11.2. His maternal half-brother also carried a chromosome 22q11.2 deletion. His mother has similar facial features and hypoparathyroidism. Autoimmune problems associated with chromosome 22q11.2 deletions have been reported. We suggest that the defects in immune regulation due to Tcell de®ciency in chromosome 22q11.2 deletion syndrome may predispose to autoimmune disorders, including type I diabetes mellitus.