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Type I Collagen and Divalent Cation Shifts Disrupt Cell-Cell Adhesion, Increase Migration, and Decrease PTHrP, IL-6, and IL-8 Expression in Pancreatic Cancer Cells

โœ Scribed by Grzesiak, John J. ;Smith, Kathy C. ;Chalberg, Cheryl ;Burton, Douglas W. ;Deftos, Leonard J. ;Bouvet, Michael

Book ID
111638978
Publisher
Springer
Year
2005
Tongue
English
Weight
677 KB
Volume
36
Category
Article
ISSN
1537-3649

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## Abstract We have demonstrated recently that PTHrP is upregulated in pancreatic adenocarcinoma and that the ECM exerts regulatory control, at least in part, over PTHrP expression. In our present study, we examined the potential signaling interactions between these 2 pathways. Our results demonstr