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Type-C oncovirus isolate from human leukemic bone marrow: Further in vitro and in vivo characterization

✍ Scribed by K. Nooter; J. Overdevest; R. Dubbes; G. Koch; P. Bentvelzen; C. Zurcher; J. Coolen; J. Calafat

Book ID
102866824
Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
954 KB
Volume
21
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Rabbit corneal cells transformed by a putative human type‐C helper virus pseudotype of the mouse sarcoma virus produce large amounts of transforming and non‐transforming viruses. The virions are antigenically related to the woolly monkey (simian) sarcoma‐leukemia type‐C oncovirus. Typical sarcoma virus lesions developed in newborn rats injected with virus‐producing rabbit cells. Cells producing only the putative type‐C helper viruses as a result of exposure to a high dilution of transforming virus stock induce lymphosarcomas after inoculation into newborn rats.

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