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t(y;18) in acute myeloblastic leukemia FAB type M2

✍ Scribed by Sheila N. Jani Sait; Paola Dal Cin; Avery A. Sandberg

Book ID
119103165
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
168 KB
Volume
22
Category
Article
ISSN
0165-4608

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Mutations of CEBPA in acute myeloid leuk
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CEBPA encodes the transcription factor C/EBPalpha and is specifically up-regulated during granulocytic differentiation. The gene is mutated in approximately 20% of patients with acute myeloid leukemia (AML) FAB type M2 and occurs in the absence of the t(8;21). In much the same way as specific transl