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Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

โœ Scribed by Gudmundsson, Julius; Sulem, Patrick; Steinthorsdottir, Valgerdur; Bergthorsson, Jon T; Thorleifsson, Gudmar; Manolescu, Andrei; Rafnar, Thorunn; Gudbjartsson, Daniel; Agnarsson, Bjarni A; Baker, Adam


Book ID
109919582
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
263 KB
Volume
39
Category
Article
ISSN
1061-4036

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Two variants on chromosome 17 confer pro
โœ Gudmundsson, Julius; Sulem, Patrick; Steinthorsdottir, Valgerdur; Bergthorsson, ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 263 KB

We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome