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Two Unusual Phenolic Substances and One New Xanthone from Hypericum sampsonii

✍ Scribed by Wen-Bo Xin; Gui-Lin Jin; Zhu-Jun Mao; Lu-Ping Qin


Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
214 KB
Volume
94
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

Sampsone A (1), a novel prenylated aromatic lactone, and sampsone B (2), an unusual dihydrodibenzodioxinone, together with sampsone C (3), a new xanthone, were isolated from the aerial parts of Hypericum sampsonii. Their structures were determined by spectroscopic methods which were mainly 1D‐ and 2D‐NMR techniques, and the structure of sampsone B (2) was also confirmed by X‐ray crystallographic analysis. All of these compounds were evaluated for in vitro antibacterial activity against methicillin‐resistant Staphylococcus aureus (MRSA). Only sampsone A showed moderate antibacterial activities at a minimum inhibitory concentration (MIC) of 32 μg/ml.


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