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Two-substrates packed-bed bioreactors: inhibition of enzyme and competitive binding of substrate and product to a ligand

✍ Scribed by N. Lotan; S. Sideman; S. Guzy


Book ID
104744205
Publisher
Springer
Year
1991
Tongue
English
Weight
582 KB
Volume
7
Category
Article
ISSN
1615-7605

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Electron redistribution on binding of a
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## Abstract The migration of electron density of a substrate (folate) on binding to an enzyme (dihydrofolate reductase) is studied by a quantum‐mechanical method originally developed in solid state physics. A significant polarization of the substrate is induced by the enzyme, toward the transition