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Two-step synthesis of new 1,2,4,5-tetrahydrospiro-[3H-2-benzazepine-3,4′-piperidines] from 4-iminopiperidines

✍ Scribed by Palma R. Alirio; Sandra Salas; Vladimir Kouznetsov; Elena Stashenko; Montenegro N. Gisela; Fontela G. Angel

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
60 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

New spiro[3__H__‐2‐benzazepine‐3,4′‐piperidines] and their precursors, N‐substituted 4‐allyl‐4‐N‐benzyl‐aminopiperidines, have been prepared as potential psychotic agents from readily available 4‐iminopiperidines, by a sequence of reactions that included nucleophilic addition of Grignard reagents and Bronsted acid‐mediated intramolecular cyclisation. Some of the compounds prepared have been tested in albine mice for spontaneous motor activity. All compounds prepared were characterized by ir and ^1^H nmr spectroscopies and cg‐ms spectrometry.

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