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Two-stage k-sample designs for the ordered alternative problem

โœ Scribed by Guogen Shan; Alan D. Hutson; Gregory E. Wilding

Book ID
112183459
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
229 KB
Volume
11
Category
Article
ISSN
1539-1604

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## Abstract We propose optimized twoโ€stage designs for genomeโ€wide caseโ€control association studies, using a hypothesis testing paradigm. To save genotyping costs, the complete marker set is genotyped in a subโ€sample only (stage I). On stage II, the most promising markers are then genotyped in the