Two-stage enriched enrolment pain trials: A brief review of designs and opportunities for broader application

The application of a two-stage design fo

The application of a two-stage design for clinical trials in patients with recurrent head and neck cancer

✍ Eisenberger, Mario A. ;Ellenberg, Susan ;Leyland-Jones, Brian ;Friedman, Michael 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 620 KB

Cytotoxic chemotherapy produces modest benefits for patients with recurrent and metastatic squamous cell carcinoma of the head and neck (SCCHN). Prospective randomized clinical trials have failed to demonstrate unequivocal superiority of aggressive multidrug regimens over single agents. Despite this