Two-Site Binding of β-Cyclodextrin to the Alzheimer Aβ(1−40) Peptide Measured with Combined PFG-NMR Diffusion and Induced Chemical Shifts †

Translational diffusion measured by PFG-

Translational diffusion measured by PFG-NMR on full length and fragments of the Alzheimer Aβ(1–40) peptide. Determination of hydrodynamic radii of random coil peptides of varying length

✍ Jens Danielsson; Jüri Jarvet; Peter Damberg; Astrid Gräslund 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB

## Abstract PFG‐NMR methods were used to measure the translational diffusion coefficients for the Aβ peptide involved in Alzheimer's disease and also for a series of fragments of this peptide. The peptides ranged from a pentamer to the full length Aβ(1–40). They were studied at 25° C and physiologi