Two signals are involved in polyclonal B cell stimulation by T helper type 2 cells: a role for LFA-1 molecules and interleukin 4
✍ Scribed by Michael Lohoff; Andreas Koch; Martin Röllinghoff
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 376 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Two signals are involved in polyclonal Bcell stimulation by T helper type 2 cells: a role for
Institut fur Klinische Mikrobiologie LFA-1 molecules and interleukin 4* der Universitat Erlangen-Nurnbeig, Erlangen T helper cell type 2 (T1,2) cells when triggered by antibodies to CD3 acquire the capacity to stimulate the polyclonal proliferation of syngeneic, resting B cells.
Here, we tested the ability of various monoclonal antibodies (mAb) to block the B cell proliferation-inducing potential of such activated Th2 cells.We demonstrate that anti-interleukin 4, as well as anti-LFA-1 antibodies interfere with theT-B cell interaction. In kinetic studies, anti-LFA-1 was found to be operative during the first half and anti-interleukin 4 during the second half of the 48-h culture period. This defines at least two different steps in Bcell triggering by Th2cells. In addition, the data imply that the T-B cell interaction involves an additional structure, namely an activation molecule, on the Tcell surface.