Two secreted retinal factors regulate different stages of development of the outer blood–retinal barrier

Remodeling of junctional complexes durin

Remodeling of junctional complexes during the development of the outer blood-retinal barrier

✍ Williams, Christopher D. ;Rizzolo, Lawrence J. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 767 KB

Background: The retinal pigment epithelium (RPE) forms the outer blood-retinal barrier by separating the neural retina from fenestrated capillaries in the choroid. The barrier depends upon tight junctions within the apical junctional complexes that bind neighboring cells. During development, permeab