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Two putative tumor suppressor genes on chromosome arm 8p may play different roles in prostate cancer

โœ Scribed by Kazuo Oba; Hideyasu Matsuyama; Satoru Yoshihiro; Fumio Kishi; Mutsuo Takahashi; Manabu Tsukamoto; Mitsuru Kinjo; Kazuyuki Sagiyama; Katsusuke Naito


Book ID
114134905
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
184 KB
Volume
124
Category
Article
ISSN
0165-4608

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Loss of heterozygosity studies of a variety of human tumors suggest that there are several tumor suppressor genes on chromosome arm 8p. To localize these genes more precisely. we utilized polymerase chain reaction amplification of microsatellie repeat polymorphism and examined the allelic IOU patter

High frequency of deletion on chromosome
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Chromosome 9p has been reported to be a critical region of loss in various cancers. Our present study was designed to determine the frequency of deletions at different loci of chromosome 9p in microdissected samples of normal prostatic epithelium and carcinoma from the same patients. For this purpos