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Two polymorphic mutations (c2331A>C and IVS11+142insAGAAATTTTAAGTCTT) in the human peroxin 1 gene (PEX1)

✍ Scribed by N. Preuss; J. Gärtner


Book ID
102262160
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
18 KB
Volume
17
Category
Article
ISSN
1059-7794

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✍ Drakoulis, N. ;Cascorbi, I. ;Brockm�ller, J. ;Gross, C.R. ;Roots, I. 📂 Article 📅 1994 🏛 Springer-Verlag 🌐 English ⚖ 940 KB

Genetic differences in the metabolism of carcinogens may codetermine individual predisposition to cancer. Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1. Two point mutations have been reported, ml in