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Two photoaffinity analogs of HTI-286, a synthetic analog of hemiasterlin, interact with alpha-tubulin

Book ID
117659736
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
124 KB
Volume
38
Category
Article
ISSN
0959-8049

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## Abstract Therapeutic resistance is the underlying cause for most cancer deaths and a major problem associated with treatment of metastatic prostate cancer. HTI‐286, a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport‐based re