𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Two novel SCN9A mutations causing insensitivity to pain

✍ Scribed by K.B. Nilsen; A.K. Nicholas; C.G. Woods; S.I. Mellgren; M. Nebuchennykh; J. Aasly


Book ID
116818864
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
104 KB
Volume
143
Category
Article
ISSN
0304-3959

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Congenital insensitivity to pain: novel
✍ James J. Cox; Jony Sheynin; Zamir Shorer; Frank Reimann; Adeline K. Nicholas; Lo πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 879 KB

SCN9A encodes the voltage-gated sodium channel Na v 1.7, a protein highly expressed in pain-sensing neurons. Mutations in SCN9A cause three human pain disorders: bi-allelic loss of function mutations result in Channelopathy-associated Insensitivity to Pain (CIP), whereas activating mutations cause s