Two novel pyrrole-imidazole alkaloids from the Mediterranean sponge Agelas oroides

✍ Scribed by Ernesto Fattorusso; Orazio Taglialatela-Scafati

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 75 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01764-0

✦ Synopsis

The novel pyrrole-imidazole alkaloids cyclooroidin (7) and taurodispacamide A (8) have been isolated from the Mediterranean sponge Agelas oroides, and their structures established from spectroscopic data. Although both these alkaloids may be conceived as derivatives of the C 11 N 5 skeleton of the known oroidin (1), remarkably cyclooroidin (7) possesses the unprecedented N1/C9 connection. Taurodispacamide A (8) exhibited a good antihistaminic activity, tested on the isolated guinea pig ileum.