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Two novel point mutations of mitochondrial tRNA genes in histologically confirmed Parkinson disease

✍ Scribed by Eva M. Grasbon-Frodl; Siegfried Kösel; Mathias Sprinzl; Ulrich von Eitzen; Parviz Mehraein; M. B. Graeber


Book ID
106257454
Publisher
Springer
Year
1999
Tongue
English
Weight
103 KB
Volume
2
Category
Article
ISSN
1364-6745

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We used a genetic approach to study the nuclear factors involved in the biogenesis of mitochondrial tRNAs. A point mutation in the mitochondrial tRNA ASp gene of Saccharomyces cerevisiae had previously been shown to result in a temperature-sensitive respiratory-deficient phenotype as a result of the