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Two Novel Olean Triterpenoids from Celastrus hypoleucus

✍ Scribed by Kui-wu Wang; Hong-xiang Sun; Bin Wu; Yuan-jiang Pan

Publisher
John Wiley and Sons
Year
2005
Tongue
German
Weight
173 KB
Volume
88
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Two new triterpenoids, (3__β__)‐olean‐12‐ene‐3,23‐diol (1) and (6__α__)‐6‐hydroxyolean‐12‐en‐3‐one (2) were isolated from the MeOH extract of the stalks of Celastrus hypoleucus (Oliv.) Warb., together with the seven known compounds (3__β__,22__α__)‐3,22‐dihydroxyolean‐12‐en‐29‐oic acid, β‐amyrin and β‐amyrin palmitate, wilforlide A, wilforilide B, palmitic acid, and β‐sitosterol. Their structures were elucidated on the basis of spectroscopic data and, in the case of 2, by X‐ray crystallography. Compound 1 showed moderate cytotoxicity against human cervical squamous carcinoma (Hela) cells.

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