Two novel ent-kaurane diterpenoids isolated from Isodon eriocalyx var. laxiflora

✍ Scribed by Xuemei Niu; Shenghong Li; Qinshi Zhao; Zhongwen Lin; Handong Sun; Yang Lu; Cheng Wang; Qitai Zheng

• Book ID: 104232270
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 239 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02229-8

✦ Synopsis

Two novel 3,6-epoxy-6,7:8,15-seco-7,20-olide-ent-kaurane diterpenoids laxiflorin F (1) and laxiflorin G (2) have been isolated from the leaves of Isodon eriocalyx var. laxiflora. The structure elucidation of 1 and 2 was accomplished by spectroscopic methods including 2D NMR analysis. The relative stereochemistry of 1 was established by single crystal X-ray crystallography, which also confirmed the novel carbon skeleton of the new ent-kaurane diterpenoid. Both compounds were tested for their cytotoxicity toward human leukemia K562 cells.