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Two new structured intermediates in the oxidative folding of RNase A

✍ Scribed by Ervin Welker; Mahesh Narayan; Michael J Volles; Harold A Scheraga


Book ID
117111628
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
75 KB
Volume
460
Category
Article
ISSN
0014-5793

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## Abstract The replacement of tryptophan 59 of ribonuclease T1 by a tyrosine residue does not change the stability of the protein. However, it leads to a strong acceleration of a major, proline‐limited reaction that is unusually slow in the refolding of the wild‐type protein. The distribution of f