Two New Steroidal Saponins from the Processed Polygonatum kingianum

✍ Scribed by He-Shui Yu; Bai-Ping Ma; Xin-Bo Song; Li-Ping Kang; Tao Zhang; Jing Fu; Yang Zhao; Cheng-Qi Xiong; Da-Wei Tan; Li-Juan Zhang; Jie Zhang; Kate Yu

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: German
• Weight: 186 KB
• Volume: 93
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900308

✦ Synopsis

Abstract

Two new spirostanol saponins, kingianoside I (1) and kingianoside K (2), corresponding to (3__β__,23__S__,25__R__)‐23‐hydroxy‐12‐oxospirost‐5‐en‐3‐yl 4‐O‐β‐D‐glucopyranosyl‐β‐D‐galactopyranoside (1) and (3__β__,25__R__)‐7‐oxospirost‐5‐en‐3‐yl α‐L‐arabinofuranosyl‐(1→4)‐[6‐deoxy‐α‐L‐mannopyranosyl‐(1→2)]‐β‐D‐glucopyranoside (2), along with 13 known compounds, daucosterol, (25__R__)‐kingianoside G, (25__RS__)‐kingianoside A, pratioside D~1~, (25__RS__)‐pratioside D~1~, (25__S__)‐kingianoside C, kingianoside C, ginsenoside Rb~1~, saponins Tb and Pb, dioscin, gracillin, and saponin Pa, were isolated from the processed rhizomes of Polygonatum kingianum. The structures of the new compounds were elucidated by detailed spectroscopic analyses, including 1D‐ and 2D‐NMR techniques, and chemical methods. Compound 2 contains a novel unusual spirostanol saponin aglycone. Ginsenoside Rb~1~ and saponin Tb were isolated for the first time from the genus Polygonatum. The 13 known compounds were detected for the first time in the processed Polygonatum kingianum.