Two New Prenylated Xanthones from the Pericarp of Garcinia mangostana (Mangosteen)

✍ Scribed by Xiaojun Zhou; Riming Huang; Jing Hao; Huijuan Huang; Manqin Fu; Zhifang Xu; Yongmei Zhou; Xu-E Li; Samuel X. Qiu; Bin Wang

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 191 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201100157

✦ Synopsis

Abstract

Two new prenylated xanthones (=9__H__‐xanthen‐9‐ones), garcimangosxanthones D (1) and E (2), together with the six known xanthones 3–8, were isolated from the pericarp of Garcinia mangostana. Their structures were determined by analysis of their spectroscopic data. All of the isolated compounds were biologically evaluated for their in vitro cytotoxic activity against A549, Hep‐G2, and MCF‐7 human‐cancer cell lines and antioxidant activity. Compound 1 exhibited moderate cytotoxicity against Hep‐G2 (IC~50~=19.2 μM) and weak cytotoxicity against MCF‐7 (IC~50~=62.8 μM) cell lines, and compound 2 showed moderate cytotoxicity against A549, Hep‐G2, and MCF‐7 cell lines with IC~50~ values of 12.5–20.0 μM (Table 2). Both compounds 1 and 2 demonstrated a weak antioxidant activity with ferric reducing antioxidant power (FRAP) values of 41±7 and 130±4 μmol/g, respectively (Table 3).