Two new paracetamol/dioxane solvates—a system exhibiting a reversible solid-state phase transformation
✍ Scribed by Ranko M. Vrcelj; Nathan I.B. Clark; Alan R. Kennedy; David B. Sheen; Evelyn E.A. Shepherd; John N. Sherwood
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 146 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
This work reports on the crystal structures of two dioxane solvates of paracetamol that are true polymorphs. The high temperature phase is an orthorhombic form, space group Pbca, Z ¼ 8, a ¼ 12.6078(3) A ˚, b ¼ 12.1129(2) A ˚, c ¼ 13.4138(3) A ˚, V ¼ 2048.52(7) A ˚3, (at 295 K) and the low temperature form is monoclinic, space group
(at 123 K). The structures of these polymorphs are described as is the interrelationship between the two structures. In addition to the structural interrelationship, it is shown that the two forms undergo a reversible phase transformation. Desolvation of either form generates the stable monoclinic phase of paracetamol.