Two New Eremophilane-Type Sesquiterpenoids from the Rhizomes of Ligularia veitchiana (Hemsl.) Greenm

✍ Scribed by Cai-Fang Wang; Yu Zhao; Yan-Ze Liu; Zhen-Zhong Zhang

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: German
• Weight: 176 KB
• Volume: 91
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200890187

✦ Synopsis

Abstract

Two new eremophilane‐type sesquiterpenoids eremophil‐6‐en‐11‐ol (1) and (7__α__,9__α__,10__α__)‐9,10‐epoxy‐eremophilan‐11‐ol (2), together with a known eremophilane‐type (6__α__,8__α__)‐6,8‐dihydroxyeremophil‐7(11)‐en‐12‐oic acid 12,8‐lactone (3) were isolated from the rhizomes of Ligularia veitchiana. The structures of 1 and 2 were established by spectral analysis including ^1^H‐ and ^13^C‐NMR, HSQC, HMBC, and HR‐ESI‐MS data. The compounds 1 and 3 were assessed against lung‐cancer (A549) and stomach‐cancer (BCG823) cell lines by the MTT method. The results showed that 1 exhibited significant inhibiting activities on the growth of these cancer cells with IC~50~ values between 1–100 μg/ml, whereas compound 3 had no effect on the same cell lines.