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Two new efficient preparations of enantiopure 2,2′-dihydroxy-6,6′-dimethoxy-1,1′-biphenyl

✍ Scribed by Giovanna Delogu; Davide Fabbri

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
315 KB
Volume
8
Category
Article
ISSN
0957-4166

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✦ Synopsis

Two new useful methods for the preparation of diol 1 starting from available compounds are described. Separation of the two enantiomers entails resolution of racemic diol 1 via the corresponding diastereomeric N-methylated phosphorothioamidates. Their separation by recrystallization followed by reduction afforded diol (aS)-I and (aR)-I in 100% and 72% ee, respectively.

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