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Two new cytotoxic cytochalasins from Xylaria obovata

✍ Scribed by Ermias Dagne; A.A.Leslie Gunatilaka; Senait Asmellash; Dawit Abate; David G.I. Kingston; Glenn A. Hofmann; Randall K. Johnson

Book ID
104203416
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
492 KB
Volume
50
Category
Article
ISSN
0040-4020

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✦ Synopsis

Two new cytotoxic cytochalasins were isolated by brine shrimp bioassay-guided fractionation from a culture of the wood inhabiting fungus, Xylnria obovata. Their structures were determined as 19,20-epoxycytochalasin Q (1) and its deacetyl analog 2 by the application of spectroscopic techniques and chemical correlation with cytochalasin R. Acetylation of 2 yielded 1. Both 1 and 2 were cytotoxic but were found to be inactive in an HIV-protease inhibitory assay and a mechanism-based DNA damaging yeast assay.

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✍ Ziming Chen; Hongbo Huang; Yuchan Chen; Zhongwen Wang; Junying Ma; Bo Wang; Weim 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 German ⚖ 175 KB 👁 1 views

## Abstract Two new cytochalasins, 18‐deoxycytochalasin Q (**1**) and 21‐__O__‐deacetylcytochalasin Q (**2**), together with four known analogues, cytochalasin Q (**3**), 19,20‐epoxycytochalasin Q (**4**), 21‐__O__‐deacetyl‐19,20‐epoxycytochalasin Q (**5**), and cytochalasin D (**6**), were isolate