A new iridoid, torrilliolide (1), and a new pyridine alkaloid, torricelline (2), were isolated from the stem barks of Torricellia tiliifolia. Their structures were determined by analysis of their spectroscopic data. Both compounds exhibited cytotoxicity against Spodoptera litura cell line. Introduction. -Torricellia tiliifolia DC., belonging to the family Torricelliaceae, is distributed in southwest of China and north of India. Its barks are used for alleviating bruises, swelling, and pain from traumatic injury including falls, sprains, fractures, and contusions in Chinese medicine [1]. During our search for pesticidal plants growing in southwest of China, the MeOH extract of this plant was found to possess a potent activity against Musca domestica vicina Macquart, Tribolium castaneum (Herbst), Spodoptera litura Fabricius, Culex pipiens quinquefasciatus Say, and Ostrinia furnacalis (Guene' e) [2]. The chemical constituents of this plant were, therefore, investigated, and a new iridoid, torrilliolide (1), and a new pyridine alkaloid, torricelline (2), were isolated. Here, we report the isolation, structure elucidation, and cytotoxicity of these new compounds.