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Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens

✍ Scribed by Jing-Ru Weng; Horng-Huey Ko; Ting-Li Yeh; Hsien-Cheng Lin; Chun-Nan Lin

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
83 KB
Volume
337
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

Two new arylnaphthalide lignans, procumphthalide A (1) and 4‐O‐β‐D‐glucopyranosyl‐(1‴→2″)‐β‐D‐apiofuranosyldiphyllin, named procumbenoside B (2), along with cilinaphthalide B (3) and several other known compounds were isolated from the methanolic extracts of Justicia procumbens. By using NMR and other spectral methods, the structures of 1 and 2 were elucidated. Cilinaphthalide B (3), justicidin A (4), and taiwan E methyl ether (5) were shown to have an antiplatelet effect in human plateletrich plasma. In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration‐dependent manner, with an IC~50~ value of about 27.6 μM.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v