Two human genes encoding zinc finger proteins, ZNF12 (KOX 3) and ZNF 26 (KOX 20), map to chromosomes 7p22-p21 and 12q24.33, respectively
✍ Scribed by P. Seite; K. Huebner; M. F. Rousseau-Merck; R. Berger; H. J. Thiesen
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 650 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
Two members of the human zinc finger Krtippel family, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), have been localized by somatic cell hybrid analysis and in situ chromosomal hybridization. The presence of individual human zinc finger genes in mouse-human hybrid DNAs was correlated with the presence of specific human chromosomes or regions of chromosomes in the corresponding cell hybrids. Analysis of such mouse-human hybrid DNAs allowed the assignment of the ZNF 12 (KOX 3) gene to chromosome region 7p. The ZNF 26 (KOX 20) gene segregated with chromosome region 12ql3-qter. The zinc finger genes ZNF12 (KOX3) and ZNF26 (KOX20) were localized by in situ chromosomal hybridization to human chromosome regions 7p22-21 and 12q24.33, respectively. These genes and the previously mapped ZNF 24 (KOX 17) and ZNF 29 (KOX 26) genes, are found near fragile sites.