✦ LIBER ✦

Two-directional synthesis. Part 1: A short formal synthesis of (±)-histrionicotoxin and (±)-histrionicotoxin 235A

✍ Scribed by Robert A Stockman

Book ID: 104211189
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 63 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01640-3

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✦ Synopsis

The formal synthesis of (±)-histrionicotoxin and (±)-histrionicotoxin 235A using a two-directional strategy has been accomplished. The key feature of the synthesis is a tandem oxime formation/Michael addition/nitrone cycloaddition sequence, which form the azaspiro[5.5]undecane skeleton in two operations from an acyclic symmetrical precursor.

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