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Two-dimensional gel electrophoresis analysis of Syrian hamster embryo cells: Morphological transformation is not cell type specific

✍ Scribed by Dr. Robert J. Isfort; Gary Kerckaert; N. Leigh Anderson; Robert A. LeBœuf


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
628 KB
Volume
13
Category
Article
ISSN
0173-0835

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✦ Synopsis


Abstract

Studies were conducted to investigate the protein phenotype of normal and morphologically transformed Syrian hamster embryo (SHE) cells. Based upon two‐dimensional gel protein phenotype analysis, we conclude that (i) SHE cells are a mixture of multiple cell types including mesenchymal and epithelial cells and (ii) several cell types present in the SHE cell population can be morphologically transformed by a variety of genotoxic and non‐genotoxic carcinogens.