Two-dimensional and colour doppler contrast echocardiography of the right and left heart with the ultrasound contrast medium BY963 after intravenous administration in conscious dogs
✍ Scribed by P. Bubenheimer; K.D. Beller; P. Schaffer
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 1024 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0929-8266
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✦ Synopsis
Objective: To test a newly developed contrast agent for echocardiological application. Metho&
The newly developed echo contrast agent BY963 consists of phospholipid containing microbubbles (spherosomes), which were prepared by a short agitation in a specially designed mixing chamber. During agitation, a small amount of air (36&ml) was incorporated into the forming spherosomes. The contrast agent was tested after intravenous injection in six conscious male dogs (24-37kg) for its contrast-giving properties in 2-D echocardiography of the left heart. Results: Three doses of the preparation (1, 2 and 3 ml) were injected at 10 min intervals. No adverse reactions or hemodynamic changes were observed. With 2-D echocardiography (B-mode) all injections resulted in a complete and homogeneous contrast in all four heart chambers, with a dosedependent intensity and duration (diagnostic window of 20-30 s). With colour Doppler echocardiography, all injections resulted in a pronounced signal enhancement in the pulmonary vein, left atrium, mitral region and aorta descendens, with an homogeneous and clearly outlined colour area (diagnostic window about 30 s). Conclusions: Due to the different durations of the initial over-contrasted periods, the diagnostic windows of B-mode and colour Doppler examinations did not overlap, so that the B-mode and colour Doppler examination can be performed successively after one single injection.