Elevated serum chromogranin A (CgA) levels have been detected in patients with prostate cancer who have developed resistance to hormonal therapy. We would like to reexamine these cases by using serial specimens to determine whether such elevated levels are also detectable in prostate cancer patients
Two different lymph node metastatic patterns of a prostatic cancer
โ Scribed by Hiroshi Saitoh; Ken-Ichiro Yoshida; Yutaka Uchijima; Nobuyuki Kobayashi; Junji Suwata; Shigeyoshi Kamata
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 360 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0008-543X
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โฆ Synopsis
Among 753 autopsy prostatic cancer cases with a metastasis, 476 (63%) had a lymph node metastasis, whereas 277 (37%) did not. Two different lymph node metastatic patterns were observed: Type 1, combined metastasis involving the pelvic and paraaortic lymph nodes; and Type 2, metastasis to the paraaortic lymph nodes, but not to the pelvic lymph nodes. Type 1 metastasis cases showed a significantly more frequent metastasis to the bladder and rectum, and a less frequent metastasis to the lungs and liver. Hydronephrosis occurred more frequently (P < 0.01) in the Type 1. Furthermore, in the Type 1 cases the lymph node metastasis appeared to be continuously invasive, but in the Type 2 cases, metastasis appeared to be the skip type or some metastases may have spread via the vertebral vein bypass route and may have been associated with a hematogenous metastasis.
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