This study confirms the presence of a novel variable number of tandem repeats polymorphism, designated as HumDN1, in intron 4 of the human deoxyribonuclease I (DNase I) gene. Genotyping was performed without difficulty by PCR-amplification and separation by agarose gel electrophoresis in 423 Japanes
โฆ LIBER โฆ
Two deoxyribonuclease I gene polymorphisms and correlation between genotype and its activity in Japanese population
โ Scribed by Junko Fujihara; Hisakazu Takatsuka; Kaori Kataoka; Yuing Xue; Haruo Takeshita
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 107 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1344-6223
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Global genetic analysis of all single nucleotide polymorphisms in exons of the human deoxyribonuclease I-like 3 gene and their effect on its catalytic activity Deoxyribonucleases (DNases) have been suggested to be implicated in the pathophysiology of autoimmune diseases. In the DNASE1L3 gene encodin