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Two Crystal Structures of Human Neutrophil Collagenase, One Complexed with a Primed- and the Other with an Unprimed-Side Inhibitor: Implications for Drug Design †

✍ Scribed by Gavuzzo, Enrico; Pochetti, Giorgio; Mazza, Fernando; Gallina, Carlo; Gorini, Barbara; D'Alessio, Silvana; Pieper, Michael; Tschesche, Harald; Tucker, Paul A.

Book ID: 126884848
Publisher: American Chemical Society
Year: 2000
Tongue: English
Weight: 741 KB
Volume: 43
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9909589

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1.8-Å Crystal Structure of the Catalytic

1.8-Å Crystal Structure of the Catalytic Domain of Human Neutrophil Collagenase (Matrix Metalloproteinase-8) Complexed with a Peptidomimetic Hydroxamate Primed-Side Inhibitor with a Distinct Selectivity Profile

✍ Michael Betz; Philip Huxley; Stephen J. Davies; Yasmeen Mushtaq; Michael Pieper; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 915 KB