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Two Consecutive Phase II Trials of Biweekly Oxaliplatin plus Weekly 48-Hour Continuous Infusion of Nonmodulated High-Dose 5-Fluorouracil as First-Line Treatment for Advanced Colorectal Cancer

✍ Scribed by Albert Abad; Alfredo Carrato; Matilde Navarro; Javier Sastre; Andrés Cervantes; Antonio Antón; Mercedes Martinez-Villacampa; Eugenio Marcuello; Bartomeo Massutí; Enrique Aranda; José Luis Manzano; José Luis Guallar; Eduardo Diaz-Rubio


Book ID
119934976
Publisher
CIG Media Group, LP.
Year
2005
Tongue
English
Weight
101 KB
Volume
4
Category
Article
ISSN
1533-0028

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✍ Enrique Aranda; Andrés Cervantes; Javier Dorta; Esperanza Blanco; Carlos Fernánd 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB 👁 2 views

Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer