𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Two-color Raman spectroscopy for the simultaneous detection of chemotherapeutics and antioxidative status of human skin

✍ Scribed by W. Werncke; I. Latka; S. Sassning; B. Dietzek; M.E. Darvin; M.C. Meinke; J. Popp; K. König; J.W. Fluhr; J. Lademann

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
126 KB
Volume
8
Category
Article
ISSN
1612-2011

No coin nor oath required. For personal study only.

✦ Synopsis

Aiming at the development of strategies to prevent the hand-foot-syndrome, we propose to evaluate the amount of chemotherapeutics in the human skin together with carotenoids the latter serving as marker substances for the dermal antioxidative status. This approach is demonstrated by applying twocolor Raman spectroscopy at 785 and 532 nm excitation for selective detection of chemotherapeutics and carotenoids, respectively. Porcine ear skin has proven to be suited as a model for corresponding spectroscopic basic in-vitro investigations.

Raman intensity, arb. units 500 1000 1500

Wavenumber, cm -1 human skin 785 nm human skin 532 nm

Raman spectra of human skin recorded at 10 μm depth with an excitation at 785 and 532 nm, respectively. The Raman lines marked with an originate from carotenoids

📜 SIMILAR VOLUMES

Resonance Raman spectroscopy for the det
Resonance Raman spectroscopy for the detection of carotenoids in foodstuffs. Influence of the nutrition on the antioxidative potential of the skin
✍ M. E. Darvin; I. Gersonde; H. Albrecht; W. Sterry; J. Lademann 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 1 views

Various fruit, vegetables and plants contain a high amount of carotenoids such as beta-carotene, lycopene, lutein, zeaxanthin, and other antioxidants in different concentrations and combinations. These substances used by nature are an effective defense mechanism against the destructive action of fre

Non-invasive in vivo detection of the ca
Non-invasive in vivo detection of the carotenoid antioxidant substance lycopene in the human skin using the resonance Raman spectroscopy
✍ M.E. Darvin; I. Gersonde; H. Albrecht; M. Meinke; W. Sterry; J. Lademann 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 106 KB 👁 1 views

A non-invasive optical method for__in vivo__determination of the concentration of carotenoid antioxidant substance lycopene in the skin, based on resonance Raman spectroscopy, is presented. The Ar^+^laser with an excitation wavelength at 514.5 nm was used, which corresponds to the maximum of the abs