Two cases of trisomy 12p due to rcpt(12;21)(p11;p11) inherited through three generations

✍ Scribed by M. Parslow; Diana Chambers; Margaret Drummond; W. Hunter

• Book ID: 104721586
• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 458 KB
• Volume: 47
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00321017

✦ Synopsis

Two cases of trisomy 12p due to a familial translocation t(12;21) (p11;p11) inherited through three generations are presented. The clinical features of both affected individuals are consistent with those previously reported. Study of the NORs by silver staining showed translocation of the NOR from chromosome 21 onto the der(12) and suggested that the activity of this site has been suppressed in some carriers.