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Two carbon homologated ?,?-unsaturated aldehydes from alcohols using the in situ oxidation?Wittig reaction

✍ Scribed by Reid, Mark; Rowe, David J.; Taylor, Richard J. K.


Book ID
118126335
Publisher
Royal Society of Chemistry
Year
2003
Tongue
English
Weight
118 KB
Volume
18
Category
Article
ISSN
1359-7345

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In situ alcohol oxidation-Wittig reactio
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Benzylic, allylic, propargylic and unactivated alcohols can be oxidised with activated manganese dioxide in the presence of N-methoxy-N-methyl-2-(triphenylphosphoranylidine)acetamide to generate directly the corresponding a,b-unsaturated Weinreb amides. Elaboration of the resulting Weinreb amides is